Synthesis, characterization and antimicrobial activity of novel benzofuran- and thiophene-containing diketoxime derivatives | Zendy

Demet Coşkun | Zendy; Seher Gür | Zendy; Mehmet Çoşkun | Zendy

Open Access

Synthesis, characterization and antimicrobial activity of novel benzofuran- and thiophene-containing diketoxime derivatives

Author(s) -

Demet Coşkun,

Seher Gür,

Mehmet Çoşkun

Publication year - 2017

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc160517003c

Subject(s) - salmonella enterica , benzofuran , antimicrobial , escherichia coli , chemistry , staphylococcus aureus , thiophene , minimum inhibitory concentration , ether , salmonella , stereochemistry , organic chemistry , biochemistry , biology , bacteria , gene , genetics

The aim of this study was the preparation of 1,1′-(2,5-thiophenediyl) bis[1-(2-benzofuranyl)methanone] (2), the corresponding diketoxime (3), and the ether and ester derivatives (4a–e) of the diketoxime. These compounds were prepared in good yields. Minimum inhibitory concentrations (MIC) of the synthesized compounds 1–4 were determined against Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli and Staphylococcus aureus. Among the synthesized compounds, 1 and 4e showed good activity against E. coli, S. enterica and S. aureus

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