Original enzyme-catalyzed synthesis of chalcones: Utilization of hydrolase promiscuity | Zendy

Yavor Mitrev | Zendy; Aleksandar Y. Mehandzhiyski | Zendy; Daniela Batovska | Zendy; Andreas Liese | Zendy; Boris Galunsky | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Original enzyme-catalyzed synthesis of chalcones: Utilization of hydrolase promiscuity

Author(s) -

Yavor Mitrev,

Aleksandar Y. Mehandzhiyski,

Daniela Batovska,

Andreas Liese,

Boris Galunsky

Publication year - 2016

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc160422069m

Subject(s) - acetophenone , chalcone , chemistry , benzaldehyde , catalysis , imidazole , enzyme , stereochemistry , organic chemistry , combinatorial chemistry

E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (3.5.1.14) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (3.5.1.81) catalyzed also the reaction between acetophenone and p-nitrobenzaldehyde. Such “green” approach to synthesis of chalcones is of great interest, because of their important applications as formula ingredients in pharmaceutical, food and cosmetic industry

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research