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The present study was aimed to investigate the elicitation possibility of the   main secondary metabolites production in Nepeta cataria L. and N. pannonica   L. plants, by exposing them to synthetic compounds from the group of   tetraoxanes and tiophenes. The effect of DO63 (1,2,4,5-tetraoxane) and   DOVF15 (2,5-diphenyl-tiophene) on the production of cis,trans-nepetalactone   (NL) and rosmarinic acid (RA) in two Nepeta species, was investigated in   shoots grown on culture medium with addition of synthetic compounds in   concentrations ranging from 0.1 to 2 mg L-1. The content of targeted   metabolites in tested in vitro shoots depended on the type and the   concentration of applied synthetic compounds. Application of DO63, primarily   in concentration of 0.1 mg L-1 to 1 mg L-1, affected only NL production in   both Nepeta species resulting in increased NL content in treated shoots,   while production of RA was not influenced. Addition of DOVF15 caused   decrease of RA content in N. pannonica shoots and increase in N. cataria   shoots, whereas NL production was not affected. The presented results   highlight the possibility of DO63 and DOVF15 application for the elicitation   of the main secondary metabolites production in species from the genus   Nepeta. [Projekat Ministarstva nauke Republike Srbije, br. 172008 i br.   173024

Elicitation effects of synthetic 1,2,4,5-tetraoxane and 2,5-diphenyltiophene in shoot cultures of two Nepeta species