Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives | Zendy

Kulathooran Singaram | Zendy; Dhamodaran Marimuthu | Zendy; Selvakumar Baskaran | Zendy; Venkataraman Ramaswamy | Zendy

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Synthesis and antimicrobial activity of new 3,5-diarylidene-4-piperidone derivatives

Author(s) -

Kulathooran Singaram,

Dhamodaran Marimuthu,

Selvakumar Baskaran,

Venkataraman Ramaswamy

Publication year - 2016

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc151112043s

Subject(s) - antimicrobial , aspergillus niger , aspergillus fumigatus , chemistry , antifungal , aspergillus , combinatorial chemistry , stereochemistry , organic chemistry , microbiology and biotechnology , biochemistry , biology

Three series of heteroaromatic analogs (twenty seven compounds) with monoketone linkers have been synthesized and evaluated for their antimicrobial activity against six microbial strains. Among them, 3,5-dibenzylidene-1-(3,5-dichloro-2-hydroxyphenylsulfonyl)piperidin-4-one 5e showed best antifungal activity against Aspergillus niger and Aspergillus fumigatus. Structural elucidation of the synthesized compounds was determined on the basis of various spectroscopic methods

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