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Neurobiological activity of the methanol extracts of thirteen Umbelliferae   (Apiaceae) plants was tested against acetylcholinesterase (AChE),   butyrylcholinesterase (BChE), and tyrosinase (TYR) using high-throughput   screening technique. Although the extracts displayed none to low profile of   inhibition against enzymes, the highest cholinesterase inhibition was   observed with Heracleum platytaenium (32.52 ± 3.27 % for AChE and 46.16 ±   1.42 % for BChE) at 100 μg mL-1. Since neurodegeneration is linked to   oxidative damage, antioxidant potential of the extracts was searched through   radical scavenging, metal-chelating capacity, and reducing power experiments   and exerted modest levels of activity varying according to the method. The   extracts had a better ability to scavenge nitric oxide radical (19.47 ± 2.09   % to 54.91 ± 1.98 %). Since these species are known to be rich in coumarins,   our quantitative high-performance liquid chroatography (HPLC) analysis   indicated presence of xanthotoxin, angelicin, isopimpinellin, bergapten, and   pimpinellin in Heracleum platytaenium and angelicin and imperatorin in   Angelica sylvestris var. sylvestris

journal of the serbian chemical society

Cholinesterase, tyrosinase inhibitory and antioxidant potential of randomly selected Umbelliferous plant species and chromatographic profile of Heracleum platytaenium Boiss. and Angelica sylvestris L. var. sylvestris