Synthesis and antimicrobial evaluation of some novel thiomorpholine derived 1,4-disubstituted 1,2,3-triazoles | Zendy

Kumaraswamy Battula | Zendy; Sirassu Narsimha | Zendy; Vasudevareddy Nagavelli | Zendy; Priyanka Bollepelli | Zendy; M. S. Narasinga Rao | Zendy

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Synthesis and antimicrobial evaluation of some novel thiomorpholine derived 1,4-disubstituted 1,2,3-triazoles

Author(s) -

Kumaraswamy Battula,

Sirassu Narsimha,

Vasudevareddy Nagavelli,

Priyanka Bollepelli,

M. S. Narasinga Rao

Publication year - 2015

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc150818088b

Subject(s) - sodium azide , antimicrobial , chemistry , antifungal , cycloaddition , combinatorial chemistry , alkyl , antibacterial activity , halide , stereochemistry , medicinal chemistry , organic chemistry , microbiology and biotechnology , catalysis , bacteria , biology , genetics

A convenient synthesis of novel1,4-disubstituted 1,2,3-triazoles (4a-j & 5a-j) is reported via copper (I) - catalyzed one pot [3+2] cycloaddition of various alkyl halides, sodium azide with (prop-2-yn-1-yl)thiomorpholine and 4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide. All the synthesized compounds were investigated for their antimicrobial activity. Compounds 4a, 4b, 4c, 4g, 5a and 5j against S.epidermidis, 4a, 5a and 5d against P. aeroginosa, 4a, 4b and 4g against K.pneumoniae, 4b, 5a and 5d against S.aureus and 5b, 5e and 5j against B.Subtilis have shown excellent antibacterial activity compared to the standard drugs Penicillin and Streptomycin. Compounds 4c, 4e, 4f, 4j, 5c, 5d, 5g and 5j have registered moderate antifungal activity as compared with standard drug Ampothericin-B

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