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A convenient synthesis of novel1,4-disubstituted 1,2,3-triazoles (4a-j &   5a-j) is reported via copper (I) - catalyzed one pot [3+2] cycloaddition of   various alkyl halides, sodium azide with (prop-2-yn-1-yl)thiomorpholine and   4-(prop-2-yn-1-yl)thiomorpholine 1,1-dioxide. All the synthesized compounds   were investigated for their antimicrobial activity. Compounds 4a, 4b, 4c, 4g,   5a and 5j against S.epidermidis, 4a, 5a and 5d against P. aeroginosa, 4a, 4b   and 4g against K.pneumoniae, 4b, 5a and 5d against S.aureus and 5b, 5e and 5j   against B.Subtilis have shown excellent antibacterial activity compared to   the standard drugs Penicillin and Streptomycin. Compounds 4c, 4e, 4f, 4j, 5c,   5d, 5g and 5j have registered moderate antifungal activity as compared with   standard drug Ampothericin-B

Synthesis and antimicrobial evaluation of some novel thiomorpholine derived 1,4-disubstituted 1,2,3-triazoles