Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole | Zendy

Vesna Vasić | Zendy; Jelena Z. Penjišević | Zendy; Ireovaković | Zendy; Vladimir Šukalović | Zendy; Deana Andrić | Zendy; Sladjana KostićRajačić | Zendy

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Synthesis and biological evaluation of 5-substituted derivatives of benzimidazole

Author(s) -

Vesna Vasić,

Jelena Z. Penjišević,

Ireovaković,

Vladimir Šukalović,

Deana Andrić,

Sladjana KostićRajačić

Publication year - 2013

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc130418058v

Subject(s) - benzimidazole , chemistry , proteus vulgaris , candida albicans , clostridium sporogenes , bacillus subtilis , staphylococcus aureus , microbiology and biotechnology , antibacterial activity , escherichia coli , biology , organic chemistry , biochemistry , bacteria , clostridium , genetics , gene

Series of eight novel 5-substituted derivatives of benzimidazole were synthesized by condensation of corresponding diamine with ethyl-4-[4-(2-chlorophenyl)piperazin-1-yl] butanoate in refluxing 4N hydrochloric acid. In vitro antibacterial activity against ten strains namely, Bacillus subtilis, Clostridium sporogenes, Streptosporangium longisporum, Micrococcus flavus, Sarcina lutea, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis and Proteus vulgaris and antifungal activity against two fungal strains namely, Candida albicans and Saccharomyces cerevisiae, were evaluated. Of all the compounds screened for activity 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-iodo-1H-benzimidazole and 2-{3-[4-(2-chlorophenyl)piperazin-1-yl]propyl}-5-methyl-1H-benzimidazole were associated with higher antifungal activity than commercial drugs. [Projekat Ministarstva nauke Republike Srbije, br. 172032

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