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Given that oxidative stress plays a major role in pancreatic β-cell  dysfunction and ultimate destruction, as well as in different complications  of diabetes, therapy with antioxidants has assumed an important place in  diabetes management. The relatively limited effects of established  antioxidant compounds have stimulated efforts to develop new therapeutic  strategies, e.g. to increase the endogenous antioxidant defenses through  pharmacological modulation of key antioxidant enzymes. Plant extracts are  gaining popularity in treating diabetes because many substances synthesized  by higher plants and fungi possess antioxidant activities and can prevent or  protect tissues against the damaging effects of free radicals. This review  summarizes experimental models of diabetes and possible mechanisms that lie  behind the antioxidative effects of α-lipoic acid (LA), a powerful  antioxidant and compound that stimulates cellular glucose uptake, as well as  of plant extracts from sweet chestnut (Castanea sativa), edible mushroom  (Lactarius deterrimus) and natural products containing β-glucans in the  treatment of diabetes. Their roles in preventing pancreatic β-cell death and  in ameliorating the effects of severe diabetic complications are discussed.  [Projekat Ministarstva nauke Republike Srbije, br. 173020

Ameliorating effects of antioxidative compounds from four plant extracts in experimental models of diabetes