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The polydentate ligand,  3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one, was  synthesized by intermolecular cyclocondensation reaction of  2-hydroxybenzaldehyde thiosemicarbazone and ethylchloroacetate. Novel  palladium(II) complex was obtained by nucleophilic substitution of both DMSO  ligands from cis-[Pd(DMSO)2Cl2] with iminic nitrogen and thiolactamic sulfur  from ligand. The structure of compounds was characterized on the basis of  their spectral data. The cytotoxic activity of the ligand and palladium(II)  complex was studied on tumor cell lines: human colon carcinoma HCT-116 and  SW-480 cells using MTT viability test. The results show that investigated  palladium(II) complex has significantly greater cytotoxic effect compared to  ligand. [Projekat Ministarstva nauke Republike SRbije, br. 172011 and  III41010

Synthesis, characterization and cytotoxicity of palladium(II) complex of 3-[(2-hydroxy-benzylidene)-amino]-2-thioxo-imidazolidin-4-one