Electroanalytical determination of metronidazole in tablet dosage form | Zendy

Selehattin Yılmaz | Zendy; Esra Baltaoglu | Zendy; Gulsen Saglikoglu | Zendy; Sultan Yağmur | Zendy; Kamran Polat | Zendy; Murat Sadıkoğlu | Zendy

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Electroanalytical determination of metronidazole in tablet dosage form

Author(s) -

Selehattin Yılmaz,

Esra Baltaoglu,

Gulsen Saglikoglu,

Sultan Yağmur,

Kamran Polat,

Murat Sadıkoğlu

Publication year - 2012

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc120111069y

Subject(s) - metronidazole , dosage form , chemistry , chromatography , pharmacology , medicine , antibiotics , biochemistry

In this study, the electrochemical reduction and determination of metronidazole were easily realized in Britton-Robinson buffer (pH = 4.01) using UTGE by cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques. In this acidic medium, one irreversible and sharp cathodic peak was observed. A linear calibration curve for DPV analysis was constructed in the metronidazole concentration range 3x10-6 - 9x 10-5 mol L-1. Limit of detection (LOD) and limit of quantification (LOQ) were 1.42x10-7 and 4.76x10-7 mol L-1 respectively

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