Microwave-assisted multi-component synthesis of 3’-indolyl substituted pyrano[2,3-c]pyrazoles and their antimicrobial activity | Zendy

Harshad G. Kathrotiya | Zendy; Ranjan G. Patel | Zendy; Manish Patel | Zendy

Open Access

Microwave-assisted multi-component synthesis of 3’-indolyl substituted pyrano[2,3-c]pyrazoles and their antimicrobial activity

Author(s) -

Harshad G. Kathrotiya,

Ranjan G. Patel,

Manish Patel

Publication year - 2011

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc110805199k

Subject(s) - antimicrobial , broth microdilution , chemistry , candida albicans , combinatorial chemistry , microwave irradiation , yield (engineering) , bacillus subtilis , pyrazole , microbiology and biotechnology , minimum inhibitory concentration , stereochemistry , organic chemistry , bacteria , biology , materials science , catalysis , metallurgy , genetics

A series of pyrano[2,3-c]pyrazole derivatives of indole has been synthesized by multi-component reaction using conventional and microwave irradiation approach. Particularly valuable features of this method include high yield, broad substrate scope, shorter reaction time and straightforward procedure. Antimicrobial screening against eight human pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli, A. fumigatus and C. albicans by employing broth microdilution MIC method as recommended by NCCLS

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