Synthesis and in vitro anti breast cancer activity of some novel 1,5-benzothiazepine derivatives | Zendy

Keshav Lalit Ameta | Zendy; Nitu S. Rathore | Zendy; Biresh Kumar | Zendy

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Synthesis and in vitro anti breast cancer activity of some novel 1,5-benzothiazepine derivatives

Author(s) -

Keshav Lalit Ameta,

Nitu S. Rathore,

Biresh Kumar

Publication year - 2011

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc110715219a

Subject(s) - in vitro , chemistry , elemental analysis , proton nmr , carbon 13 nmr , combinatorial chemistry , microwave irradiation , breast cancer , cytotoxicity , condensation reaction , fourier transform infrared spectroscopy , condensation , cancer cell lines , nuclear chemistry , organic chemistry , cancer , cancer cell , biochemistry , chemical engineering , medicine , physics , engineering , thermodynamics , catalysis

The title compounds 3a-j, substituted 1,5-benzothiazepines were synthesized by the condensation of variously substituted chalcones 1 and 2- aminothiophenol 2 via conventional as well as non-conventional inorganic solid support microwave irradiation methods. The non-conventional protocol offers several advantages such as simple procedure, fast reaction rate, mild reaction conditions and improved yields compared to conventional methods. The structures of the products 3a-j were established by elemental analysis, FTIR, 1H-NMR, 13C-NMR and mass spectroscopic studies. The synthesized compounds have also been evaluated for the cytotoxicity against human breast cancer cell line MDA-MB-435 with some exhibiting in vitro anti-breast cancer activities

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