Mechanisms of the interaction between Pr(DNR)3 and Herring-Sperm DNA | Zendy

Xiaocai Liu | Zendy; Xingming Wang | Zendy; LiSheng Ding | Zendy

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Mechanisms of the interaction between Pr(DNR)3 and Herring-Sperm DNA

Author(s) -

Xiaocai Liu,

Xingming Wang,

LiSheng Ding

Publication year - 2011

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc100826121l

Subject(s) - intercalation (chemistry) , dna , enthalpy , chemistry , herring , sperm , binding constant , base pair , crystallography , thermodynamics , binding site , biochemistry , genetics , biology , inorganic chemistry , physics , fishery , fish <actinopterygii>

Research on the interaction mechanism of drugs with DNA is essential to understand their pharmacokinetics. The interaction between rare earth complexes Pr(DNR)3 and Herring-Sperm DNA was studied in Tris-HCl buffer solution (pH 7.4) by absorption and fluorescence spectroscopy and viscosity measurements. The results showed that the modes of interaction between Pr(DNR)3 and Herring-Sperm DNA were electrostatic and intercalation. The binding ratio was nPr(DNA)3 ׃ nDNA = 5׃1 and the binding constant was KΘ292K = 4.34×10exp3 L mol-1. Furthermore, according to the double reciprocal method and the thermodynamic equation, the intercalative interaction was cooperatively driven by an enthalpy effect and an entropy effect

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