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An efficient and practical synthesis of 1,3,5-trisubstituted 2-pyrazo- line structures was achieved through cyclization of phenylhydrazine with α,β- -unsaturated ketones (chalcones) using methanoic acid (formic acid) as catalyst under thermal condition.

Synthesis and characterization of a series of 1,3,5-trisubstituted-2-pyrazolines derivatives using methanoic acid under thermal condition