New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity | Zendy

Ștefania Felicia Bărbuceanu | Zendy; Gabriela Laura Almajan | Zendy; Ioana Şaramet | Zendy; Constantin Drǎghici | Zendy; Radu Socoteanu | Zendy; Florica Bărbuceanu | Zendy

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New S-alkylated 1,2,4-triazoles incorporating diphenyl sulfone moieties with potential antibacterial activity

Author(s) -

Ștefania Felicia Bărbuceanu,

Gabriela Laura Almajan,

Ioana Şaramet,

Constantin Drǎghici,

Radu Socoteanu,

Florica Bărbuceanu

Publication year - 2009

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0910041b

Subject(s) - alkylation , phenacyl bromide , chemistry , sulfonyl , bromide , elemental analysis , ethyl chloroacetate , phenacyl , proton nmr , antibacterial activity , carbon 13 nmr , organic chemistry , catalysis , alkyl , hydrate , biology , bacteria , genetics

Alkylation of the 5-{4-((4-bromophenyl)sulfonyl)phenyl}-4-(3/4-me- thylphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones 3a,b with various alkyla- tion agents, i.e., ethyl bromide, phenacyl bromide and ethyl chloroacetate, afforded the S-substituted 1,2,4-triazoles 4-6a,b. The structures of these new compounds were elucidated by elemental analysis and IR, UV, 1 H-NMR, 13 C- -NMR and MS spectroscopy. The newly synthesized products were tested for their antibacterial effects.

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