Synthesis, thermal and antitumour studies of Th(IV) complexes with furan-2-aldehyde-N-phenyl thiosemicarbazone

Thorium(IV) complexes with the Schiff base furan-2-aldehyde- N-phenyl thiosemicarbazone (L) were synthesised and characterized. The composition and structure of the metal complexes were proposed base on elemental analysis, molar conductivity measurements, FTIR and 1 H-NMR spectroscopy. The Schiff base behaves as a neutral bidentate ligand coordinating through the azomethine N and the thioketo S atoms. From various studies, complexes were ascertained the general formula (ThL2X4) and (ThL2Y2) where X represents the monovalent anions NO3 - , NCS - , CH3COO - , CH3CHOHCOO - , ClO4 - ,and Y the bivalent anions SO4 2- and C2O4 2- . The thermal behaviour of the nitrato and oxalato complexes was studied and kinetic and thermodynamic parameters were calculated using the Coats-Redfern Equation. The ligand and a representative complex (ThL2(NO3)4) were screened in vitro for their antitumour activity against the human cervical cancer cell line (Hela).