Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites | Zendy

Jadranka Odović | Zendy; Mirjana Aleksić | Zendy; Biljana Stojimirović | Zendy; Dušanka MilojkovićOpsenica | Zendy; Živoslav Tešić | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Normal-phase thin-layer chromatography of some angiotensin converting enzyme (ACE) inhibitors and their metabolites

Author(s) -

Jadranka Odović,

Mirjana Aleksić,

Biljana Stojimirović,

Dušanka MilojkovićOpsenica,

Živoslav Tešić

Publication year - 2009

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0906677o

Subject(s) - lipophilicity , chemistry , chromatography , thin layer chromatography , phase (matter) , enzyme , solvent , angiotensin converting enzyme , stereochemistry , biochemistry , organic chemistry , endocrinology , medicine , blood pressure

The separation and chromatographic behaviour of five ACE (angio- tensin converting enzyme) inhibitors and their four active metabolites were investigated by normal-phase thin-layer chromatography on silica using several mono- and binary non-aqueous solvent systems. The linear relationship be- tween the RM values and the composition of employed mobile phase was ob- tained. The hydrophobicity parameters 0 R and C0 were determined from the regression data of the plots, analogous to reversed-phase chromatography. The chromatographically obtained hydrophobicity parameters were correlated with the calculated log P values. The current results were correlated with the lipo- philicity of the studied ACE inhibitors and their metabolites, previously esti- mated by reversed-phase chromatography.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research