Open AccessAcid-base equilibria of the Zn(II) and Fe(III) complexes with condensation products of 2-acetylpyridine and the dihydrazide of oxalic and malonic acid
Author(s) -
Branka Dražić,
Gordana Popović,
Ratomir Jelić,
Dušan Sladić,
Dragana Mitić,
Katarina Andjelković,
Živoslav Tešić
Publication year - 2009
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0903269d
Subject(s) - protonation , chemistry , oxalic acid , ionic strength , malonic acid , ligand (biochemistry) , equilibrium constant , aqueous solution , base (topology) , medicinal chemistry , inorganic chemistry , acid–base reaction , deprotonation , zinc , ion , organic chemistry , receptor , mathematical analysis , biochemistry , mathematics
Acid-base equilibria of Zn(II) and Fe(III) complexes with N',N'2-bis-[(1E)-1-(2-pyridyl)ethylidene]ethanedihydrazide (ligand L1) and N',N'2-bis[(1E)-- 1-(2-pyridyl)ethylidene]propanedihydrazide (ligand L2), i.e., [Fe(L1)Cl 2 (H 2 O)], [Fe(L2)Cl(H 2 O)] 2+ , [Zn(L1)(H 2 O) 3 ] + and [Zn(L2)(H 2 O) 2 ] 2+ , which expressed cytotoxic activity, were investigated in aqueous media. The equilibrium constants were determined potentiometrically at 25 °C at a constant ionic strength of 0.10 mol/dm 3 (Na 2 SO 4 ). The results showed that at pH < 8 both the Fe(III) complexes studied here have three, while [Zn(L1)(H 2 O) 3 ] + and [Zn(L2)(H 2 O) 2 ] 2+ have one and two titratable protons, respectively. Based on the obtained values for the equilibrium constants, protonation schemes of the examined complexes are proposed.
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