Synthesis and antimicrobial, antifungal and anthelmintic activities of 3h-1,5-benzodiazepine derivatives | Zendy

Rajesh Kumar | Zendy; Yogesh Joshi | Zendy

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Synthesis and antimicrobial, antifungal and anthelmintic activities of 3h-1,5-benzodiazepine derivatives

Author(s) -

Rajesh Kumar,

Yogesh Joshi

Publication year - 2008

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0810937k

Subject(s) - antimicrobial , chemistry , anthelmintic , antifungal , sodium salt , pyrazole , sodium hydroxide , salt (chemistry) , medicinal chemistry , organic chemistry , nuclear chemistry , inorganic chemistry , microbiology and biotechnology , ecology , biology

The diazonium salt of 4-amino-1-methyl-3-propyl-1H-pyrazole-5-car- boxamide in the presence of sodium hydroxide was condensed with different β-diketones/β-ketoesters, 3a-e, to obtain new β-diketones/β-ketoesters, 4a-e. The β-diketones/β-ketoesters 4a-e were condensed with o-phenylenediamine (o-PDA) in presence of p-toluenesulfonic acid/SiO2 to give biologically active 3H-1,5- -benzodiazepines, 5a-e. All the newly synthesized compounds were characteri- zed by elemental analysis and spectral studies. The compounds 5a-e were screened for their antimicrobial, antifungal and anthelmintic activities.

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