Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine | Zendy

Dragana Mitić | Zendy; D.U. Miodragovic | Zendy; Dušan Sladić | Zendy; Željko Vitnik | Zendy; Z.M. Miodragović | Zendy; Katarina Andjelković | Zendy; Milanka Radulović | Zendy; Nenad Juranić | Zendy

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Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine

Author(s) -

Dragana Mitić,

D.U. Miodragovic,

Dušan Sladić,

Željko Vitnik,

Z.M. Miodragović,

Katarina Andjelković,

Milanka Radulović,

Nenad Juranić

Publication year - 2008

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0809815m

Subject(s) - chemistry , carbon 13 nmr , elemental analysis , proton nmr , ligand (biochemistry) , nuclear magnetic resonance spectroscopy , crystallography , antimicrobial , alanine , stereochemistry , inorganic chemistry , organic chemistry , amino acid , biochemistry , receptor

In this study, the first complexes of Zn(II) with the N-benzyloxycar- bonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1 H-NMR, 13 C-NMR and 2D-NMR spectroscopy. On the basis of the experi- mental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that (Zn(N-Boc-S-ala)2) was selective and acts only on Candida albicans.

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