Open AccessSynthesis, structural characterization and cytotoxic activity of two new organoruthenium(II) complexes
Author(s) -
Sanja GrgurićŠipka,
Arbi Alshtewi,
Dejan Jeremić,
Goran Kaludjerovic,
Santiago GómezRuiz,
Željko Žižak,
Zorica D. Juranić,
Tibor J. Sabo
Publication year - 2008
Publication title -
journal of the serbian chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.227
H-Index - 45
eISSN - 1820-7421
pISSN - 0352-5139
DOI - 10.2298/jsc0806619g
Subject(s) - ruthenium , p cymene , chemistry , ligand (biochemistry) , semicarbazone , stereochemistry , crystal structure , elemental analysis , spectroscopy , crystallography , inorganic chemistry , organic chemistry , physics , biochemistry , receptor , quantum mechanics , catalysis
Two new p-cymene ruthenium(II) complexes containing as additional ligands N-methylpiperazine (((η 6 -p-cymene)RuCl2(CH3NH(CH2)4NH))PF6, com- plex 1) or vitamin K3-thiosemicarbazone (((η 6 -p-cymene)RuCl2(K3tsc)), com- plex 2) were synthesized starting from ((η 6 -p-cymene)2RuCl2)2 and the cor- responding ligand. The complexes were characterized by elemental analysis, IR, electronic absorption and NMR spectroscopy. The X-ray crystal structure de- termination of complex 1 revealed "piano-stool" geometry. The differences in the cytotoxic activity of the two complexes are discussed in terms of the ligand
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