Cytotoxic and antimicrobial activities of two new synthetic 2'-oxygenated flavones reported from andrographis viscosula | Zendy

Sohel Mostahar | Zendy; Sayed Alam | Zendy; Azizul Islam | Zendy

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Cytotoxic and antimicrobial activities of two new synthetic 2'-oxygenated flavones reported from andrographis viscosula

Author(s) -

Sohel Mostahar,

Sayed Alam,

Azizul Islam

Publication year - 2007

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0704321m

Subject(s) - flavones , chalcone , chemistry , antimicrobial , acanthaceae , carbon 13 nmr , brine shrimp , flavonoid , organic chemistry , proton nmr , stereochemistry , traditional medicine , antioxidant , chromatography , botany , biology , medicine

Two new 2'-oxygenated flavones have been synthesized via chalcone pre- cursors and the biocidal activity of these two flavones, along with the corresponding chalcones against microbes (bacteria and fungi) and brine shrimp nauplii were investi- gated. Both the flavones (compounds 6 and 7) and their corresponding chalcones (compounds 4 and 5) showed good activity against all the tested bacterial and fungal strains. The LC50 values of compounds 4- 7 were found to be 2.31, 0.94, 1.39 and 0.58 gm L -1 , respectively. The synthesized compounds were characterized using UV-Vis, IR, 1 H-NMR and 13 C-NMR spectral data, together with elemental analysis.

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