Synthesis and antimycobacterial activity of novel heterocycles | Zendy

Mohammad Shahar Yar | Zendy; Ahmad Siddiqui | Zendy; Ashraf Ali | Zendy

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Synthesis and antimycobacterial activity of novel heterocycles

Author(s) -

Mohammad Shahar Yar,

Ahmad Siddiqui,

Ashraf Ali

Publication year - 2007

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0701005y

Subject(s) - antimycobacterial , hydrate , hydrazine (antidepressant) , chemistry , ethanol , pyrazoline , condensation , combinatorial chemistry , organic chemistry , mycobacterium tuberculosis , condensation reaction , tuberculosis , chromatography , catalysis , medicine , pathology , physics , thermodynamics

In the present investigation 4-hydroxy-3-methylacetophenone on conden- sation with various aromatic aldehydes in methanolic KOH solution yielded the cor- responding chalcones (CI-CXI). These chalcones were further reacted with hydrazi- ne hydrate in ethanol which led to the formation of pyrazoline derivatives (HI-HXI). The newly synthesized heterocyles were characterized on the basis of their chemical properties and spectroscopic data. All newly synthesized compounds were evalu- ated for their antimycobacterial activities against Mycobacterium tuberculosis H37Rv.

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