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New functionally substituted 5-arylidene-2,4-dioxotetrahydro 1,3-thiazole- 3-carboxylic acid cholesteryl esters were synthesized from 2,4-dioxotetrahydro- 1,3-thiazole and evaluated for their in vitro cytotoxicity against several human tumor cell lines and one normal lung fibroblast cell line.

Synthesis and biological activity evaluation of new functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazoles