Synthesis and antibacterial activity of some Schiff base complexes

Two Schiff bases were synthesized from raceacetophenone: 1) ADS1: 4-et- hyl-6-{(E)-1-((3-nitrophenyl)imino)ethyl}benzene-1,3-diol and 2) ADS3: 4-eth- yl-6-{(E)-1-((2-nitrophenyl)imino)ethyl}benzene-1,3-diol. Then their metal comple- xes were formed. The metals selected for the preparation of complexes were copper, nickel, iron and zinc. Hence, in total 8 metal complexes were synthesized and screened for antibacterial activity against some clinically important bacteria, such as Pseudomo- nas aeruginosa, Proteus vulgaris, Proteus mirabilis, Klebsiella pneumoniae and Staph- ylococcus aureus .T hein vitro antibacterial activity was determined by the Agar Ditch technique using DMF (polar) and 1,4-dioxane (non polar) as solvents. The Schiff bases showed greater activity than their metal complexes; the metal complexes showed differ- ential effects on the bacterial strains investigated and the solvent used, suggesting that the antibacterial activity is dependent on the molecular structure of the compound, the solvent used and the bacterial strain under consideration. The Schiff base ADS3 in the polar solvent DMF showed better antibacterial activity towards the investigated bacte- rial strains. Amongst the four metals, Zn showed the best antibacterial activity followed by Fe in 1,4-dioxane while Ni followed by Zn and Fe showed the best antibacterial ac- tivity in DMF. P. vulgaris was the most resistant bacteria.