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Prolonging the circulation of an imaging agent is vital for making it suit- able for blood pool (vascular) imaging. Medical applications of vascular imaging in- clude cardiovascular disease, abnormal capillary permeability, and tumor neovascu- larity. As low molecular weight computerized tomography (CT) enhancement agents are characterized by inconveniently fast clearance, macromolecular com- pounds (both natural and synthetic) have gained a wide recongnition for possessing better characteristics for performing blood imaging tasks. Herein, the syntheses and characterization of a new water-soluble triiodo amino acid, 3-(N,N-dimethylami- noacetyl)amino)--ethyl-2,4,6-triiodobenzenepropanoic acid (DMAA-IPA) and its Starburst PAMAM generation 4.0 dendrimer conjugate, G-4-(DMAA-IPA)37 are de- scribed. The applicability of G-4-(DMAA-IPA)37 as a potential macromolecular angiographic CT contrast agent is discussed. The linear relationship between organ- ically bound iodine concentration and CT Hounsfield units has been established thus allowing for quantification uses of CT imaging as well.

A water-soluble triiodo amino acid and its dendrimer conjugate for computerized tomography (CT) imaging