A water-soluble triiodo amino acid and its dendrimer conjugate for computerized tomography (CT) imaging | Zendy

Alexander T. Yordanov | Zendy; Nikolay Mollov | Zendy; Adriana Lodder | Zendy; Eric K. Woller | Zendy; Mary J. Cloninger | Zendy; Stuart Walbridge | Zendy; Diane E. Milenic | Zendy; Martin W. Brechbiel | Zendy

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A water-soluble triiodo amino acid and its dendrimer conjugate for computerized tomography (CT) imaging

Author(s) -

Alexander T. Yordanov,

Nikolay Mollov,

Adriana Lodder,

Eric K. Woller,

Mary J. Cloninger,

Stuart Walbridge,

Diane E. Milenic,

Martin W. Brechbiel

Publication year - 2005

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0502163y

Subject(s) - hounsfield scale , conjugate , dendrimer , chemistry , amino acid , computed tomography , macromolecule , tomography , molecular imaging , medicine , radiology , biochemistry , in vivo , mathematical analysis , mathematics , microbiology and biotechnology , biology

Prolonging the circulation of an imaging agent is vital for making it suit- able for blood pool (vascular) imaging. Medical applications of vascular imaging in- clude cardiovascular disease, abnormal capillary permeability, and tumor neovascu- larity. As low molecular weight computerized tomography (CT) enhancement agents are characterized by inconveniently fast clearance, macromolecular com- pounds (both natural and synthetic) have gained a wide recongnition for possessing better characteristics for performing blood imaging tasks. Herein, the syntheses and characterization of a new water-soluble triiodo amino acid, 3-(N,N-dimethylami- noacetyl)amino)--ethyl-2,4,6-triiodobenzenepropanoic acid (DMAA-IPA) and its Starburst PAMAM generation 4.0 dendrimer conjugate, G-4-(DMAA-IPA)37 are de- scribed. The applicability of G-4-(DMAA-IPA)37 as a potential macromolecular angiographic CT contrast agent is discussed. The linear relationship between organ- ically bound iodine concentration and CT Hounsfield units has been established thus allowing for quantification uses of CT imaging as well.

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