7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity | Zendy

Igor Opsenica | Zendy; Nataša Terzić | Zendy; Dejan Opsenica | Zendy; Wilbur K. Milhous | Zendy; Bogdan A. Šolaja | Zendy

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7, 8, 15, 16-Tetraoxa-dispiro [5. 2. 5. 2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity

Author(s) -

Igor Opsenica,

Nataša Terzić,

Dejan Opsenica,

Wilbur K. Milhous,

Bogdan A. Šolaja

Publication year - 2004

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0411919o

Subject(s) - artemisinin , chemistry , ketone , chloroquine , carboxylic acid , malaria , medicinal chemistry , stereochemistry , hexadecane , plasmodium falciparum , organic chemistry , biology , immunology

Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains, with N-(2-dimethylamino)ethyl-7,8,15,16-tetraoxa-dispiro S5.2.5.2Chexadecane-3-carboxamide being as active as artemisinin.

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