Synthesis of the 4’-desmethoxy analogue of RU79115 | Zendy

Branislav Musicki | Zendy; Anne-Marie Periers | Zendy; Nicole Tessot | Zendy; Michel Klich | Zendy

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Synthesis of the 4’-desmethoxy analogue of RU79115

Author(s) -

Branislav Musicki,

Anne-Marie Periers,

Nicole Tessot,

Michel Klich

Publication year - 2004

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0411855m

Subject(s) - biological activity , dna gyrase , in vitro , chemistry , antibacterial activity , stereochemistry , structure–activity relationship , combinatorial chemistry , biochemistry , biology , bacteria , escherichia coli , genetics , gene

The synthesis, and biological activity in vitro of the 4’-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4’-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.

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