Spectrophotometric investigation of famotidine-Pd(II) complex and its analytical application in drug analysis | Zendy

Z. Korićanac | Zendy; Tatijana Jovanovic | Zendy; Jelena Petkovic | Zendy; Dragica Minic-Popovic | Zendy

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Spectrophotometric investigation of famotidine-Pd(II) complex and its analytical application in drug analysis

Author(s) -

Z. Korićanac,

Tatijana Jovanovic,

Jelena Petkovic,

Dragica Minic-Popovic

Publication year - 2004

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0406485k

Subject(s) - famotidine , chemistry , ionic strength , palladium , ionic bonding , chloride , chromatography , ion , analytical chemistry (journal) , nuclear chemistry , inorganic chemistry , organic chemistry , catalysis , aqueous solution , medicine

By using different spectrophotometric methods, it was found that famotidine and palladium(II) ions form a complex, Pd(II) : famotidine = 1:1, which has an absorption maxi- mum at 345 nm. The formation of the complex between famotidine and palladium(II) chlo- ride in Britton-Robinson buffer solution in the pH range 2.23-8.50 was studied. The condi- tional stability constant of the complex at the optimum pH 2.62 and ionic strength 0.5 M was found to be log K'= 3.7420.025.TheBeer'slawwasverifiedoverthefamotidineconcen- trationrangefrom510 -5 -6 10 -4 M. The proposed method was found to be suitable for ac- curate and sensitive analysis of famotidine both as the substance (RSD = 1.02-1.80 %) and its dosage forms (RSD = 1.75-1.83 %).

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