Factorial design in isocratic high-performance liquid chromatography of phenolic compounds | Zendy

Antonije Onjia | Zendy; Tatjana Vasiljević | Zendy; Djuro Cokesa | Zendy; Mila Laušević | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Factorial design in isocratic high-performance liquid chromatography of phenolic compounds

Author(s) -

Antonije Onjia,

Tatjana Vasiljević,

Djuro Cokesa,

Mila Laušević

Publication year - 2002

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0211745o

Subject(s) - chromatography , chemistry , resolution (logic) , high performance liquid chromatography , methanol , phenols , acetic acid , factorial experiment , fractional factorial design , capacity factor , column chromatography , organic chemistry , mathematics , computer science , statistics , artificial intelligence

A multifactor optimization strategy was utilized to predict the isocratic HPLC separation of nine phenols. The retention behavior was studied as a function of changing eluent (methanol - acetic acid) composition. The predicted and measured re- tentions are in rather good agreement. To locate the optimum in the factor space, the normal- ized resolution product criterion was applied. In virtually every case, the resolution is limited by the separation of the 2-chlorophenol and 2,4-dinitrophenol pair.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research