Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-nitrophenyl)-2-phenylacetamide | Zendy

Vida Jankovic | Zendy; Dušan Mijin | Zendy; Slobodan Petrović | Zendy

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Alkylation of N-substituted 2-phenylacetamides: Benzylation of N-(4-nitrophenyl)-2-phenylacetamide

Author(s) -

Vida Jankovic,

Dušan Mijin,

Slobodan Petrović

Publication year - 2002

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0206373j

Subject(s) - chemistry , toluene , alkylation , potassium hydroxide , benzyl chloride , reactivity (psychology) , catalysis , chloride , potassium , medicinal chemistry , hydroxide , organic chemistry , medicine , alternative medicine , pathology

N-(4-Nitrophenyl)-2-phenylacetamide was alkylated with benzyl chloride in the presence of powdered potassium hydroxide at different temperatures and in various solvents in order to establish the reactivity and orientation in the reaction. The reactions were also carried out in the presence of different phase-transfer catalysts in toluene. Product formation was followed by GC. The obtained results were compared to the results of the benzylation of other N-substituted 2-phenylacetamides, especially of N-phenyl-2-phenylacetamide.

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