Synthesis of higher sugars as precursors for the synthesis of chiral polyhydroxylated macrocyclic lactones | Zendy

Momčilo Miljković | Zendy; Margaret Habash-Marino | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Synthesis of higher sugars as precursors for the synthesis of chiral polyhydroxylated macrocyclic lactones

Author(s) -

Momčilo Miljković,

Margaret Habash-Marino

Publication year - 2000

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0007497m

Subject(s) - chemistry , hydroxymethyl , wittig reaction , carbohydrate , organic chemistry , stereochemistry , coupling reaction , combinatorial chemistry , catalysis

A general method for the synthesis of higher sugars that can be used as precursors for the synthesis of polyhydroxylatedmacrocyclic lactones (macrolides) was described. The extension of the carbohydrate chain of a hexopyranose was effected at its C(6) hydroxymethyl carbon by coupling of two carbohydrate precursors via Wittig reaction. In this way 6,7-dideoxy-2,3,4,5,8,9,10-hepta-O-methyl-11-O-triphenylmethyl-D-arabino-D-glucoundecanose diethyl dithioacetal (1) was synthesized as a model compound.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research