Structure and function of yeast alcohol dehydrogenase | Zendy

Svetlana Trivić | Zendy; Vladimir Leskovac | Zendy

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Structure and function of yeast alcohol dehydrogenase

Author(s) -

Svetlana Trivić,

Vladimir Leskovac

Publication year - 2000

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0004207t

Subject(s) - chemistry , hydride , yeast , stereochemistry , cofactor , enzyme , alcohol dehydrogenase , substrate (aquarium) , biochemistry , microbiology and biotechnology , biology , organic chemistry , ecology , hydrogen

Yeast alcohol dehydrogenase (EC 1.1.1.1) is a member of a large family of zinc-containing alcohol dehydrogenases. The primary structures of 47 members of this family have been determined and aligned and an evolutionary tree was constructed, assuming a divergent evolution froma common ancestral gene.1 In thisway, it was possible to identify four divergent groups of alcohol dehydrogenases (ADH) in this family: vertebrates, plants, eukaryotic microorganisms and prokaryotic bacteria. Bakers yeast (Saccharomyces cerevisiae), a member of the third group, has three isoenzymes of alcohol dehydrogenase: YADH-1, YADH-2 and YADH-3. YADH-1 is the constitutive form that is expressed during anaerobic fermentation.2 YADH-2 is another cytoplasmic form which is repressed by glucose3 and YADH-3

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