A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives | Zendy

Nada PerišićJanjić | Zendy; J.D. Janjić | Zendy; Marija Lazarevic | Zendy

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A spectrophotometric study of the protonation processes of some N-[1-(benzimidazol)-1-yl]methylbenzamide derivatives

Author(s) -

Nada PerišićJanjić,

J.D. Janjić,

Marija Lazarevic

Publication year - 2000

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc0001037p

Subject(s) - protonation , chemistry , sulfuric acid , benzimidazole , aqueous solution , amide , molecule , computational chemistry , organic chemistry , medicinal chemistry , photochemistry , ion

The protonation ofN-[1-(benzimidazol)-1-yl]methylbenzamide derivatives in aqueous acids (H2SO4) media was investigated, using a spectrophotometric method. The investigated compounds have two protonation processes. The first protonation process occurs in weakly acidic aqueous solutions (pH range) and refers to the protonation of the benzimidazole part of the molecule. The second protonation process occurs in concentrated sulfuricacidsolutionsandrefers toprotonationof theamidegroup.Theprotonationconstants of the second process were calculated by theHammett andCox-Yatesmethod. The effect of chemical structure on the ionisation constants is discussed. A correlation between the protonation constants and antimicrobial activity was established.

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