Fibronectin and C-reactive protein in pregnancy induced hypertension

Summary: Hypertension is the most common medical complication in pregnancy. Of the varying forms of hypertension that can effect pregnancy pre-eclampsia is the one specific to pegnant women. The differentional diagnosis between pre-eclampsia and pregnancy induced hypertension (PIH) is essential to proper management of pregnancy. The aim of this study was to examine the effect of hypertension on plasma fibronectin and C-reactive protein (CRP) during gestatation. The examined groups comprised 37 patients with normal pregnancy and 30 with PIH between 24 and 36 weeks of gestation. Plasma fibronectin and CRP were both assayed by nephelometric method. The obtained results for both examined parameters were significantly higher in PIH group than in controls (p < 0.05). A possitive correlation was found between fibronectin, CRP and weeks of gestation (p < 0.05). Therefore, we can conclude that plasmatic fibronectin and CRP are among useful screening parameters for estimation of the endothelial injury in hypertensive disorders of pregnancy.