The effect of ovariectomy on thyroid c cells of adult rats | Zendy

Branko Filipović | Zendy; Branka ŠošićJurjević | Zendy; Milica ManojlovićStojanoski | Zendy; Nataša Nestorović | Zendy; Verica Milošević | Zendy; Milka Sekulić | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The effect of ovariectomy on thyroid c cells of adult rats

Author(s) -

Branko Filipović,

Branka ŠošićJurjević,

Milica ManojlovićStojanoski,

Nataša Nestorović,

Verica Milošević,

Milka Sekulić

Publication year - 2002

Publication title -

jugoslovenska medicinska biohemija

Language(s) - English

Resource type - Journals

eISSN - 1452-8193

pISSN - 0354-3447

DOI - 10.2298/jmh0204345f

Subject(s) - endocrinology , medicine , calcitonin , thyroid , stereology , chemistry , immunohistochemistry , body weight , ovariectomized rat , hormone

Summary: The structure and function of C cells of adult female rats after ovariectomy (Ovx) were investigated. Intact control and Ovx rats were i.p. treated with sterile olive oil for 4 weeks. Peroxidase-antiperoxidase (PAP) immunohistochemical procedure was applied to localize calcitonin (CT) in thyroid C cells while its serum content was determined by RIA method. Morphometric analyses of the C cells volume, that of their nuclei and relative volume density included stereological method with the multipurpose test system M42. Also, the average number of C cells number per mm2 was calculated. Ovx led to a significant increase in body weight (21%; p<0.005). At the same time the C cells of Ovx rats had a significantly decreased cell volume (13%; p<0.005) and their number per mm2 was increased by 59% (p<0.001) in comparison with the controls. Ovx resulted in reduction of serum CT level by 45% comparing to the corresponding controls. Based on these data it can be concluded that Ovx inhibits both the structure and function of the C cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research