6-hydroxydopamine lesions of the striatum lead to the alterations of dopamine receptor mrna in parkinsonian rats | Zendy

Aleksandra Mladenović | Zendy; Milka Perović | Zendy; Desanka Milanović | Zendy; Selma Kanazir | Zendy; Ljubisav Rakić | Zendy; Sabera Ruždijić | Zendy

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6-hydroxydopamine lesions of the striatum lead to the alterations of dopamine receptor mrna in parkinsonian rats

Author(s) -

Aleksandra Mladenović,

Milka Perović,

Desanka Milanović,

Selma Kanazir,

Ljubisav Rakić,

Sabera Ruždijić

Publication year - 2002

Publication title -

jugoslovenska medicinska biohemija

Language(s) - English

Resource type - Journals

eISSN - 1452-8193

pISSN - 0354-3447

DOI - 10.2298/jmh0203275m

Subject(s) - striatum , hydroxydopamine , lesion , dopamine , dopamine receptor , oxidopamine , dopamine receptor d2 , medicine , basal ganglia , endocrinology , receptor , messenger rna , dopamine receptor d1 , biology , chemistry , pathology , substantia nigra , central nervous system , dopaminergic , biochemistry , gene

The effects of four-site intrastriatal 6-hydroxydopamine (6-OHDA) lesions were examined in adult male rats. Five days after the lesions the animals were checked for specific rotational behavior induced by middle dose of amphetamine and the results confirmed the effectiveness of the lesions. The RNAs from the striatum were isolated at different time points after the lesion, and the RT-PCR analyse were performed for the D1 and D2 receptor mRNA. The results show a decline in the D2 receptor mRNA level (40%) at 6 h and 24 h points while this change was not observed seven days after the lesion. In contrast, no statistically significant changes in the level of the D1 receptor mRNA after the lesion at any time point were found.

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