The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7 | Zendy

Jovan Ćirić | Zendy; Sandra Konstantinović | Zendy; Slavica Ilić | Zendy; Gordana GojgićCvijović | Zendy; Dragiša Savić | Zendy; Vlada B. Veljković | Zendy

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The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7

Author(s) -

Jovan Ćirić,

Sandra Konstantinović,

Slavica Ilić,

Gordana GojgićCvijović,

Dragiša Savić,

Vlada B. Veljković

Publication year - 2015

Publication title -

hemijska industrija

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.147

H-Index - 19

eISSN - 2217-7426

pISSN - 0367-598X

DOI - 10.2298/hemind141127019c

Subject(s) - isatin , hydrazone , streptomyces hygroscopicus , chemistry , organic chemistry , streptomyces , biology , bacteria , genetics

The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied. Isatin-3-hydrazone, 5-chloroisatin-3-hydrazone, isatin-3-tosylhydrazone, 5-chloroisatin-3-tosylhydrazone, isatin-3-(4`-hidroxy)benzoilhydrazone and 5-chloroisatin-3-(4`-hidroxy)benzoilhydrazone were synthesized in a crude glycerol, obtained during the biodiesel production from edible sunflower oil. The highest concentration of Hexaene H-85 is achieved with 5-chloroisatin-3-hydrazone (197 mg/cm3) in medium, while isatin-3-hydrazone has a greatest impact on Azalomycine B production (72 μg/cm3). [Projekat Ministarstva nauke Republike Srbije, br. III 45001

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