Photostability of piroxicam in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin | Zendy

Vesikolić | Zendy; Snežana IlićStojanović | Zendy; Ljubiša Nikolić | Zendy; Milorad Cakić | Zendy; Aleksandar Zdravković | Zendy; Á. Kapor | Zendy; Mirjana Popsavin | Zendy

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Photostability of piroxicam in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

Author(s) -

Vesikolić,

Snežana IlićStojanović,

Ljubiša Nikolić,

Milorad Cakić,

Aleksandar Zdravković,

Á. Kapor,

Mirjana Popsavin

Publication year - 2013

Publication title -

hemijska industrija

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.147

H-Index - 19

eISSN - 2217-7426

pISSN - 0367-598X

DOI - 10.2298/hemind130306034n

Subject(s) - piroxicam , fourier transform infrared spectroscopy , cyclodextrin , chemistry , coprecipitation , nuclear chemistry , proton nmr , organic chemistry , chemical engineering , medicine , alternative medicine , pathology , engineering

The aim of this work is the protection of piroxicam from photodegradation by forming inclusion complex with 2-hydroxypropyl-β-cyclodextrin. Piroxicam:2-hydroxypropyl-β-cyclodextrin molecular inclusion complex was prepared by coprecipitation method with molar ratio of 1:1. Structural characterization of the complex, the corresponding physical mixture and complexing agents of piroxicam and 2-hydroxypropyl-β-cyclodextrin was carried out by X-ray diffraction (XRD), proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared spectroscopy (FTIR). Photosensitivity to daylight for piroxicam and piroxicam:2-hydroxypropyl-β-cyclodextrin inclusion complex was investigated by Fourier-transform infrared spectroscopy. The investigations show that higher photostability of piroxicam was achieved in complex than in non-complexed piroxicam

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