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Palladium(II) complexes (1-4) of general formula [PdCl2(R2-S,S-eddp)] with  bidentate N,N’-ligands, O,O'-dialkyl esters (R = ethyl, n-propyl, n-butyl and  n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid  (S,S-eddp) were prepared and characterized by microanalysis, infrared and  UV/VIS spectroscopy. The ligands and its complexes were tested for their in  vitro antimicrobial activity against 15 species of bacteria and fungi.  Testing is performed by the microdilution method, with the minimum inhibitory  concentration (MIC) and the minimum microbicidal concentration (MMC) being  determined. The MIC values were in range from 4.9 μg cm-3 to &gt; 5000 μg cm-3  while MMC values ranged from 78 μg cm-3 to &gt; 5000 μg cm-3. Palladium(II)  complexes [PdCl2(Ln)] (n = 1-4) have statistically significant higher  activity than the corresponding ligands. The complex 4 displayed the  strongest activity among all tested compounds

hemijska industrija

Stereospecific ligands and their complexes, Part VIII: Antimicrobial activity of palladium(II) complexes with 0,0'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid