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Mucoepidermoid carcinoma (MEC) harbors a recurring t(11;19) translocation   with an associated novel fusion oncogene-MECT1-MAML2. The CRTC1-MAML2oncogene   disrupts normal cell-cycle and differentiation, contributing to tumor   development. The objectives of this study were to establish the incidence of   CRTC1-MAML2 fusion in Serbian patients and estimate its relevance as a   genetic marker of MEC behavior. In this retrospective study, 20 cases of MEC   of salivary glands were tested for the presence of CRTC1-MAML2 fusion using   reverse transcriptase-polymerase chain reaction. Clinicopathological   parameters and survival data were examined in relation to fusion status. The   CRTC1-MAML2 fusion was detected in 40% of MECs and its presence was   associated exclusively with low-intermediate grade tumor histology (P = 0.02)   and favorable clinical outcome, with 100 % overall survival rate (P=0.046).   The study has shown that the presence of the CRTC1-MAML2 fusion can serve as   an additional diagnostic and prognostic marker for mucoepidermoid carcinomas

Incidence and clinical relevance of T(11;19) translocation in salivary gland mucoepidermoid carcinoma