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In this work, the yields of resinoid and potassium obtained from aerial parts  of white lady’s bedstraw (Galium mollugo L.) by maceration, reflux extraction  and ultrasound-assisted extraction using aqueous ethanol solutions as  solvents. The main goal was to define the influence of the extraction  technique and the ethanol concentration on the resinoid and potassium yields.  The resinoid and potassium yields were determined by the solvent evaporation  from the liquid extracts to constant weight and the AAS emission method,  respectively. The dependence of resinoid and potassium yields on the ethanol  concentration was described by linear and quadratic polynomial models,  respectively. The best potassium extraction selectivity of 0.077 g K/g of dry  extract was achieved by maceration at the ethanol concentrations of 10 g/100  g. The artificial neural network (ANN) was successfully applied to estimate  the resinoid and potassium yields based on the ethanol concentration in the  extracting solvent and the time duration for all three extraction techniques  employed. The response surface methodology was also used to present the  dependence of ANN results on the operating factors. The extraction process  was optimized using the ANN model coupled with genetic algorithm. The maximum  predicted resinoid and potassium yields of 30.4 and 1.67 g/100 g of dry plant  were obtained by the ultrasonic extraction (80 min) using the 10 g/100 g  aqueous ethanol solution

chemical industry and chemical engineering quarterly

Comparison, artificial neural network modeling and genetic algorithm optimization of the resinoid and potassium yields from white lady’s bedstraw (Galium mollugo L.) by conventional, reflux and ultrasound-assisted aqueous-ethanolic extraction