Separation and lipophilicity of some new steroid derivatives in normal- and reversed-phase high performance liquid chromatography | Zendy

Marijana Ačanski | Zendy; Djura Vujuc | Zendy; Suzana Jovanović-Šanta | Zendy

Open Access

Separation and lipophilicity of some new steroid derivatives in normal- and reversed-phase high performance liquid chromatography

Author(s) -

Marijana Ačanski,

Djura Vujuc,

Suzana Jovanović-Šanta

Publication year - 2011

Publication title -

chemical industry and chemical engineering quarterly

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.189

H-Index - 26

eISSN - 2217-7434

pISSN - 1451-9372

DOI - 10.2298/ciceq110506039a

Subject(s) - chromatography , lipophilicity , chemistry , polar , high performance liquid chromatography , estrone , column chromatography , phase (matter) , steroid , reversed phase chromatography , analytical chemistry (journal) , organic chemistry , biochemistry , physics , astronomy , hormone

The separation ability and retention of normal and reversed phase HPLC with, respectively, three non-polar and two polar mobile phases, have been studied by measuring the retention constants of a series of newly synthesized estrone derivatives. The separation ability and retention are discussed in terms of the nature of the solute, eluent and stationary phase. Good correlation was found between the retention constants log k0 of newly synthesized estrone derivatives obtained on C-18 column and log P calculated by different methods

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