A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution | Zendy

Milka Avramov-Ivić | Zendy; Slobodan Petrović | Zendy; Predrag Živković | Zendy; Dušan Mijin | Zendy; K. M. Drljević | Zendy

Open Access

A study of the catalytic role of a gold electrode in the electrochemical activation of four macrolide antibiotics in sodium bicarbonate solution

Author(s) -

Milka Avramov-Ivić,

Slobodan Petrović,

Predrag Živković,

Dušan Mijin,

K. M. Drljević

Publication year - 2010

Publication title -

chemical industry and chemical engineering quarterly

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.189

H-Index - 26

eISSN - 2217-7434

pISSN - 1451-9372

DOI - 10.2298/ciceq091211017a

Subject(s) - roxithromycin , chemistry , erythromycin , cyclic voltammetry , electrochemistry , sodium bicarbonate , inorganic chemistry , tylosin , electrode , electrolyte , azithromycin , fourier transform infrared spectroscopy , catalysis , nuclear chemistry , antibiotics , organic chemistry , chemical engineering , biochemistry , engineering

Using the cyclic voltammetry, it has been shown that hydrogen evolution at a gold electrode is necessary in the electrochemical activation of azithromycin dihydrate and erythromycin A. After four hours of the potential holding at -1.2 V vs. SCE, the pH of the electrolyte has been changed from 8.40 to 8.96; from 8.40 to 8.77 in the presence of erythromycin A, and from 8.40 to 9.18 in the presence of azithromycin, indicating the reaction of the hydrogen species with antibiotics. This effect has been confirmed by using the phenolphthalein indicator and by analysing colours of the solutions by UV-Vis, as well as by FTIR spectroscopy. Under the identical experimental conditions at the gold electrode, in contrast to azithromycin dihydrate and erythromycin A, roxithromycin and midecamycin electroactivity promotion has been obtained during the first forward sweep starting from the area of a double layer region.

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