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In this study we examined if the response of the cortex against diquat (DQ),  intrastriatally (i.s.) applied to Wistar rats, was mediated by  oxidative/nitrosative stress (OS/NS). In particular, we were focused on the  glutathione (GSH) antioxidative role, thus we applied i.s. glutathione  reductase (GR) in the pre-treatment of DQ administration. Superoxide anion  radical (O2 •-), nitrate (NO3 -), malondialdehyde (MDA) and superoxide  dismutase (SOD), were measured in ipsi- and contra- lateral sides of the  cortex, at 30 minutes, 24 hours and 7 days post treatment. The redox balance  was not significantly changed in the cortex of sham operated and intact  groups. Also, no differences were observed between the ipsi- and contra-  lateral side of the cortex. Lethargy and mortality (30-40%) of the animals in  the DQ group within 24 hrs, coincided with rapidly developed lipid  peroxidation supported by OS/NS upon i.s. DQ administration. Strong redox  potential of DQ probably resulted in a huge deprivation of molecular oxygen.  The pretreatment with GR acted neuro-protectively, based on animal survival  and absence of lethargy, although, lipid peroxidation was not developed in  the GR+DQ group, OS was documented by a high concentration of O2 •- (within  24 hrs), descending and eventually inhibiting SOD activity (at 7 days).  [Projekat Ministarstva nauke Republike Srbije, br. III41018

Influence of glutathione reductase on diquat neurotoxcity assessed by oxidative/nitrosative stress in the cortex of intrastriatally treated rats