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A simple rapid liquid chromatography method for determination of enrofloxacin  in chicken plasma was developed. Samples were prepared by protein  precipitation with acetonitrile/ammonia mixture and dichloroethane  extraction. Analytical separation was performed in a gradient grade on a  Phenomenex Gemini C18 column and analytes were detected by fluorescence (λex=  300 nm and λem= 448 nm). The acidified mobile phase (pH = 3.8) was a mixture  of acetonitrile and 0.05 M acetate buffer. The method was linear in the range  0.2-3.5 μg/mL, limit of detection was 40 ng/mL and limit of quantification  was 120 ng/mL. The assay was accurate and precise and the mean recovery of  enrofloxacin was 90.07±0.89 %. The suitability of the assay for  pharmacokinetic studies was determined by measuring enrofloxacin  concentrations in chicken plasma after a single intravenous administration of  the drug at a dose of 10 mg/kg. Enrofloxacin concentration decreased from  4.17 μg/mL in 5 min to 0.32 μg/mL 24 hours after drug administration. The  obtained results confirmed the suitability of the method for enrofloxacin  determination

Determination of enrofloxacin in chicken plasma by high performance liquid chromatography for pharmacokinetic studies