Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery | Zendy

Ljiljana GojkovićBukarica | Zendy; Nataša Stojnić | Zendy; Miodrag Perić | Zendy; Jelena Cvejić | Zendy; Marko Bumbaširević | Zendy; Aleksandar Lešić | Zendy; Vitomir Ćupić | Zendy; Ivan Milošević | Zendy; Vladimir Kanjuh | Zendy

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Characteristics of the antivasoconstrictor effect of pinacidil on isolated radial artery

Author(s) -

Ljiljana GojkovićBukarica,

Nataša Stojnić,

Miodrag Perić,

Jelena Cvejić,

Marko Bumbaširević,

Aleksandar Lešić,

Vitomir Ćupić,

Ivan Milošević,

Vladimir Kanjuh

Publication year - 2010

Publication title -

acta veterinaria

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.308

H-Index - 17

eISSN - 1820-7448

pISSN - 0567-8315

DOI - 10.2298/avb1003145g

Subject(s) - pinacidil , methylene blue , chemistry , stimulation , potassium channel , vasodilation , potassium channel opener , pharmacology , contraction (grammar) , medicine , endocrinology , biochemistry , glibenclamide , photocatalysis , diabetes mellitus , catalysis

Pinacidil, a prevously studied potassium channel opener (PCO), is a potent antihypertensive agent in animals and humans. Its mechanism of action is not completly defined. The aim of our study was to investigate the antivasoconstricting effect of pinacidil on the isolated RA and to study whether this effect is endothelium-dependent. Contractions of isolated RA rings with intact endothelium were provoked by electrical field stimulation (EFS, 20 Hz) or exogenously applied noradrenaline (NA, 10 μM). Pinacidil (10 nM-0.1 mM) produced a concentration-dependent inhibition of both EFS- and NA-evoked contractions (p>0.05). NO synthesis inhibitor, L-NAME (10 μM) and the guanylate cyclase inhibitor, methylene blue (10 μM) did partly antagonize NA-evoked contractions and were without effect on EFSinduced contractions. Thus, the antivasoconstrictor effect of pinacidil on RA is partly endothelium-dependent and probably mediated via cGMP-dependent NO-pathway

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