Open AccessThe membrane active antibiotics effects on rat heart myocardium
Author(s) -
Kristina Gopčević,
Gordana Gojgić-Cvijović,
Mirjana Pavlović,
Živana Milićević,
Dragan Stevanović
Publication year - 2006
Publication title -
acta veterinaria
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.308
H-Index - 17
eISSN - 1820-7448
pISSN - 0567-8315
DOI - 10.2298/avb0603149g
Subject(s) - nigericin , inotrope , polyene , ventricle , antibiotics , polymyxin b , gramicidin , chemistry , chronotropic , medicine , pharmacology , endocrinology , membrane , biochemistry , heart rate , blood pressure
The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application