The membrane active antibiotics effects on rat heart myocardium | Zendy

Kristina Gopčević | Zendy; Gordana GojgićCvijović | Zendy; Pavlovic Mirjana | Zendy; Milicevic Zivana | Zendy; Dragan Stevanović | Zendy

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The membrane active antibiotics effects on rat heart myocardium

Author(s) -

Kristina Gopčević,

Gordana GojgićCvijović,

Pavlovic Mirjana,

Milicevic Zivana,

Dragan Stevanović

Publication year - 2006

Publication title -

acta veterinaria

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.308

H-Index - 17

eISSN - 1820-7448

pISSN - 0567-8315

DOI - 10.2298/avb0603149g

Subject(s) - nigericin , inotrope , polyene , ventricle , antibiotics , polymyxin b , gramicidin , chemistry , chronotropic , medicine , pharmacology , endocrinology , membrane , biochemistry , heart rate , blood pressure

The effect of some membrane active ionophoric antibiotics on the amplitude of contractions of isolated rat heart right ventricle was studied. The effects of polyether nigericin, polyene amphotericin B and peptide antibiotic polymyxin B were examined. Nigericin in a concentration of 1.38 _mol/L exerts a positive inotropic effect with its maximal value (+29%) 15 minutes after application. Amphotericin B in a concentration of 1.08 _mol/L caused a positive inotropic effect, which was maximal in the 30th minute of the experiment (+28%). Polymyxin B in a concentration of 0.84 _mol/L caused a positive inotropic effect, which was maximal (+32%) 20 minutes after application

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