The effect of tocopherol on serum iron content in experimental atherosclerosis | Zendy

Vucevic Danijela | Zendy; B. Peśić | Zendy; Djarmati Danica | Zendy; Gordana Djordjevic-Denic | Zendy; Tatjana Radosavljević | Zendy; Todorović Vera | Zendy; Siniša Mirković | Zendy

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The effect of tocopherol on serum iron content in experimental atherosclerosis

Author(s) -

Vucevic Danijela,

B. Peśić,

Djarmati Danica,

Gordana Djordjevic-Denic,

Tatjana Radosavljević,

Todorović Vera,

Siniša Mirković

Publication year - 2005

Publication title -

acta veterinaria

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.308

H-Index - 17

eISSN - 1820-7448

pISSN - 0567-8315

DOI - 10.2298/avb0503131v

Subject(s) - tec , immunohistochemistry , cytokeratin , phenotype , biology , pathology , thymic involution , irradiation , monoclonal antibody , chemistry , antibody , immunology , immune system , biochemistry , medicine , t cell , ionosphere , physics , astronomy , gene , nuclear physics

Phenotypic changes of thymic epithelial cells (TEC) were studied in male Wistarrats subjected to radioprotector WR-638 (358 mg/kg b.w. ip) and/or whole body X-ray irradiation (3.5 Gy) 15 days after its application. Phenotypic changes were identified in situ on cryostat thymic sections using immunohistochemical staining by a panel of monoclonal anti-cytokeratin antibodies. It was shown that WR-638 significantly reduced changes in the structure of the thymus caused by X-ray irradiation. In the primary involution phase some phenotypic characteristic changes of TEC can be explained mostly by lymphoid destruction, although factors directly connected to the protector can not be excluded. However, in the primary regenerative phase WR-638 caused prominent changes of antigen expression on subcapsular and medullary TEC in irradiated rats. Therefore, WR-638 not only protects thymocytes, but also causes alterations of phenotypic characteristics of TEC which may contribute to its beneficial radioprotective effect on the irradiated rat thymus

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