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The powder flow plays an important role in the manufacture of dosage form   such as direct compression tablets. The objective of this research was to   investigate the individual and interaction effects of magnesium stearate   (MgSt) (Merck Ltd., Germany) as lubricant and sodium starch glycolate (SSG)   (Primojel?) as superdesintegrator on powder flowability. Powder formulations   were prepared by mixing different concentration of MgSt (0.25% and 5%) and   SSG (0.5% and 4%) with microcrystalline cellulose (MCC) (Vivapur?101) or   spray-dried lactose (LAC) (Super Tab 21AN) as diluents. Eight powder   formulations were prepared using as filler LAC and MCC, as   superdesintegrator SSG and as lubricant MgSt in ratios as follows: P1 (LAC :   0.5% SSG : 0.25% MgSt); P2 (LAC : 4% SSG : 5% MgSt); P3 (LAC : 0.5% SSG : 5%   MgSt); P4 (LAC : 4% SSG : 5% MgSt); P5 (MCC : 0.5% SSG : 0.25% MgSt); P6   (MCC : 4% SSG : 5% MgSt); P7 (MCC : 0.5% SSG : 5% MgSt); P8 (MCC : 4% SSG :   0.25% MgSt). The powder formulations were evaluated using indirect methods   of flowability evaluation according to 9th European Pharmacopoeia:   measurement of tapped and bulk density (Ph.Eur.9, 2.9.34) and angle of   repose (Ph.Eur. 2.9.36). Also, compressibility index, Hausner?s ratio were   calculated. A full factorial design with three factors at two levels and   response surface methodology were applied to evaluate the influence of   various concentrations of MgSt and SSG on powder flowability. The results   indicate that flow properties improved with decrease of SSG content and with   increase of MgSt content. Magnesium stearate in powder formulations with   microcrystalline cellulose has a greater influence on the improvement of the   flow properties than powder formulations with spray-dried lactose.

The effect of magnesium stearate and sodium starch glycolate on powder flowability